Several instauration protocols exist.

All propose a way to use methadone for cancer pain when usual opioid are not adequate.

We propose a recent review of litterature highliting 7 protocols for there methodology. But still, possible dose of methadone calculated trought this 7 protocols vary greatly from 1 to 3.

Extra caution is needed for low and high Morphine Equivalent Daily Dose. We recommend a limit for MEDD <500 mg and a maximum daily dose of 100 mg.

Methadone Initiation protocols